Amazon has launched its first new language option on Amazon.com since the website was created more than two decades ago.
The company has added Spanish to the site, which will cater to more than 50 million native speakers in the US.
The US is the second-largest Spanish-speaking country in the world after Mexico.
The spokeswoman said: "Customers will be able to shop, browse and search for millions of products, view their shopping cart, and place orders in Spanish on Amazon.com and through the Amazon Mobile Shopping app.
"We will continue to roll out the shopping experience over the coming weeks.
"More and more customers should expect to see the option to shop Amazon.com in Spanish soon."
Although this rollout is new to Amazon.com in the US, a number of the retailer's overseas websites already operate in Spanish, including Amazon.com.mx in Mexico and Amazon.es in Spain.
The company has announced its plan to launch its Prime subscription service in Mexico.
In Mexico, the annual subscription fee for Prime is $46.
Amazon's sites already offer multiple languages in other countries such as in Canada, which provides both English and French; and Germany, which allows consumers shop in German, English, Dutch, Polish and Turkish.